Medical Advocates
HIV Infection/Disease
  Cryptococcal Meningitis/Meningoencephalitis
 
General Reports
Diagnosis
Clinical Management
 Drugs
Case Studies              
National Updates
Videos
 





 
Brain Main Page Main New/Newsworthy  Home Page
Last Update: May 10, 2017
 Documents identified with this icon are in Portable Document Format (PDF) and require the Adobe Acrobat Reader
General Reports
       
     Journal Papers, Abstracts, and Commentaries
 
 
FULL-TEXT ARTICLE
Cytokine patterns in a prospective cohort of HIV-infected patients with cryptococcal meningitis following initiation of antifungal and antiretroviral therapy.
Mora DJ, Ferreira-Paim K, Andrade-Silva LE, et al
PLoS One. 2017 May 9;12(5):e0176304. d.
 Paper

FULL-TEXT ARTICLE
Factors associated with early mycological clearance in HIV-associated cryptococcal meningitis.
Concha-Velasco F, González-Lagos E, Seas C, Bustamante B.
 PLoS One. 2017 Mar 29;12(3):e0174459.
 Papers

Recent advances in AIDS-related cryptococcal meningitis treatment with an emphasis on resource limited settings.
Lofgren S, Abassi M, Rhein J, Boulware DR.
 Expert Rev Anti Infect Ther. 2017 Jan 23.
Abstract

Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection.
 Naranbhai V, Chang CC, Durgiah R, et al
AIDS. 2014 Jan 21
 Abstract

Cryptococcus neoformans Ex Vivo Capsule Size Is Associated With Intracranial Pressure and Host Immune Response in HIV-associated Cryptococcal Meningitis.
 Robertson EJ, Najjuka G, Rolfes MA, et al
 J Infect Dis. 2013 Sep 6.
 Abstract

Raised intracranial pressure complicating cryptococcal meningitis: immune reconstitution
inflammatory syndrome or recurrent cryptococcal disease?
York J, Bodi I, Reeves I, Riordan-Eva P, Easterbrook PJ.
 J Infect. 2005 Jun 13;
Abstract
 
Cryptococcal meningitis.
Bicanic T, Harrison TS.
 Br Med Bull. 2005 Apr 18;72:99-118. Print 2005.
 Abstract

FULL-TEXT ARTICLE
Acute meningoencephalitis and meningitis due to primary HIV infection. 
Newton PJ, Newsholme W, Brink NS, et al..
BMJ 2002;325 1225-1227
 Paper
 
  Central nervous system infections in individuals with HIV-1 infection.
Mamidi A, DeSimone JA, Pomerantz RJ.
J Neurovirol 2002 Jun;8(3):158-67
 Abstract
 
Cryptococcal Meningitis.
Irizarry L
Curr Treat Options Neurol. 2001 Sep;3(5):413-426.
Abstract
Diagnosis/Diagnostics
       

     Journal Papers, Abstracts, and Commentaries
 
  Neuroimaging of HIV-associated cryptococcal meningitis: comparison of magnetic resonance imaging findings in patients with and without immune reconstitution.
Katchanov J, Branding G, Jefferys L,  et al
Int J STD AIDS. 2015 Feb 18.
Abstract

The clinical laboratory characteristics of 104 cases of cryptococcal  meningoencephalitis
Darze C, Lucena R, Gomes I, Melo A.
Rev Soc Bras Med Trop. 2000 Jan-Feb;33(1):21-6.
Abstract
Clinical Management
       
     Journal Papers, Abstracts, and Commentaries
 
 
The CSF immune response in HIV-1-associated cryptococcal meningitis: macrophage activation, correlates of disease severity and effect of antiretroviral therapy.
Scriven JE, Graham LM, Schutz C, et al 
J Acquir Immune Defic Syndr. 2017 Mar 24
Abstract

The Effect of Therapeutic Lumbar Punctures on Acute Mortality from Cryptococcal Meningitis.
Rolfes MA, Hullsiek KH, Rhein J,  et aj
Clin Infect Dis. 2014 Jul 23.
Abstract

Treatment of acute cryptococcal meningitis in HIV infected adults, with an emphasis
on resource-limited settings.
Sloan D, Dlamini S, Paul N, Dedicoat M.
 Cochrane Database Syst Rev. 2008 Oct 8;(4):CD005647.
Abstract
 
The use of ventriculoperitoneal shunts for uncontrollable intracranial hypertension
without ventriculomegally secondary to HIV-associated cryptococcal meningitis.
Woodworth GF, McGirt MJ, Williams MA, Rigamonti D 
Surg Neurol. 2005 Jun;63(6):529-31.
 Abstract

A clinical manifestation of AIDS with cryptococcal meningitis in Equatorial Guinea.
Wang W, Carm AR
 Trop Doct 2001 Oct;31(4):221-2
Abstract

  
     
  Cerebral infarction in chronic meningitis: a comparison of tuberculous meningitis and
cryptococcal  meningitis.
Lan SH, Chang WN, Lu CH, et al.
QJM 2001 May;94(5):247-53
 Abstract
 		  
Drugs
       
 

Antifungal Therapy

          Journal s, Abstracts, and Commentaries

  FULL TEXT ARTICLE
Early Fungicidal Activity as a Candidate Surrogate Endpoint for All-Cause Mortality in Cryptococcal Meningitis: A Systematic Review of the Evidence.
Montezuma-Rusca JM, Powers JH, Follmann D, et a
PLoS One. 2016 Aug 4;11(8):e0159727
Paper

Combination antifungal therapies for HIV-associated cryptococcal meningitis: a
randomised trial.
Brouwer AE, Rajanuwong A, Chierakul W,et al
Lancet. 2004 May 29;363(9423):1764-7.
Abstract
 

Amphotericin B      

          Journal Papers, Abstracts, and Commentaries
 
  Cryptococcosis in Australasia and the treatment of cryptococcal and other fungal
infections
with liposomal amphotericin
B.Chen SC. 
J Antimicrob Chemother 2002 Jan;49 Suppl A:57-61
Abstract		  
     
  FULL-TEXT ARTICLE
Amphotericin B colloidal dispersion combined with flucytosine with or without fluconazole
for treatment of murine cryptococcal meningitis.
Diamond DM, Bauer M, Daniel BE, et al.
Antimicrob Agents Chemother 1998 Mar;42(3):528-33
 Paper		  

Fluconazole

     Journal Papers, Abstracts, and Commentaries

 
FULL TEXT ARTICLE
 Outcome of AIDS-associated cryptococcal meningitis initially treated with 200 mg/day or
400 mg/day of fluconazole
Schaars CF ,Meintjes GA,  Morron C, et al
BMC Infectious Diseases 2006, 6:118
 Paper
 
Symptomatic Relapse of HIV-Associated Cryptococcal Meningitis after Initial Fluconazole
Monotherapy: The Role of Fluconazole Resistance and Immune Reconstitution.
Bicanic T, Harrison T, Niepieklo A, et al
Clin Infect Dis. 2006 Oct 15;43(8):1069-73.
Abstract
 
FULL-TEXT ARTICLE
Outcome of AIDS-associated cryptococcal meningitis initially treated with 200 mg/day or
400 mg/day of fluconazole.
Schaars CF, Meintjes GA, Morroni C
BMC Infect Dis. 2006 Jul 18;6:118.
 Paper
 
Antifungal susceptibilities of Cryptococcus neoformans cerebrospinal fluid isolates and clinical
outcomes of cryptococcal meningitis in HIV-infected patients with/without fluconazole prophylaxis
Manosuthi W, Sungkanuparph S, Thongyen S, et al
J Med Assoc Thai. 2006 Jun;89(6):795-802.

The efficacy of fluconazole 600 mg/day versus itraconazole 600 mg/day as
consolidation therapy of cryptococcal meningitis in AIDS patients.
Mootsikapun P, Chetchotisakd P, Anunnatsiri S, Choksawadphinyo K.
J Med Assoc Thai 2003 Apr;86(4):293-8
Abstract

Itraconazole       

     Journal Papers, Abstracts, and Commentaries
 
  A controlled trial of itraconazole as primary prophylaxis for systemic fungal infections in
patients with advanced human immunodeficiency virus infection in Thailand.
Chariyalertsak S, Supparatpinyo K, Sirisanthana T, et al.
Clin Infect Dis 2002 Jan 15;34(2):277-84
Abstract		  

ARV Drugs  

     Journal Papers, Abstracts, and Commentaries
 
  The CSF immune response in HIV-1-associated cryptococcal meningitis: macrophage activation, correlates of disease severity and effect of antiretroviral therapy.
Scriven JE, Graham LM, Schutz C, et al
J Acquir Immune Defic Syndr. 2017 Mar 24
Abstract

Optimal timing for antiretroviral therapy initiation in patients with HIV infection and concurrent cryptococcal meningitis.
Njei B, Kongnyuy EJ, Kumar S, et al
Cochrane Database Syst Rev. 2013 Feb 28;2:CD009012.
Abstract

Early versus delayed antiretroviral therapy and CSF fungal clearance in adults with HIV and cryptococcal meningitis.
 Bisson GP, Molefi M, Bellamy S, et al
Clin Infect Dis. 2013 Jan 29. .
 Abstract

Discontinuation of Maintenance Therapy for Cryptococcal Meningitis in Patients with AIDS
Treated with Highly Active Antiretroviral Therapy: An International Observational Study.
Mussini C, Pezzotti P, Miro JM, et al 
Clin Infect Dis
2004 Feb 15;38(4):565-571
Abstract
 
     Conference Reports, Abstracts, and Posters
 
  Early vs Delayed ART in the Treatment of Cryptococcal Meningitis in Africa
A Makadzange, C Ndhlovu, K Takarinda, et al 
(16 CROI)
Abstract
Case Studies
       
     Journal Papers, Abstracts, and Commentaries
 
 
Reversible Deafness and Blindness in a Patient with Cryptococcal Meningitis in Tanzania.
Douglas-Vail M, Bechamp T, Gohal S,  et al
Infect Dis Rep. 2015 Dec 22;7(4):6173
Abstract

Symptomatic relapse of HIV-associated cryptococcal meningitis: Recurrent cryptococcal meningitis or cryptococcus-related immune reconstitution inflammatory syndrome?
 Jhamb R, Kashyap B, Das S,  et al
 Int J STD AIDS. 2013 Oct 9
 Abstract

FULL-TEXT ARTICLE
 Fatal meningococcal meningitis in a HIV-infected patient caused by serogroup C Neisseria
meningitidis belonging to the non-hypervirulent clonal complex ST-60 (cc60).
Andrade CF, Cunha DC, Cavalcanti V, Filippis I.
 Braz J Infect Dis. 2011 Apr;15(2):178-80.
 Paper

Cryptococcal Meningoencephalitis Related to HIV Infection with Resistance to Fluconazole, Relapse, and IRIS.
Seilmaier M, Hecht A, Guggemos W, Rüdisser K. 
Med Klin (Munich). 2009 Jan;104(1):58-62.
Abstract
 
Cryptococcal Meningitis Manifesting as a Large Abdominal Cyst in a HIV-Infected Patient with a
CD4 Count Greater than 400 cells/mm(3).
Crum-Cianflone N, Truett A, Wallace MR.
 AIDS Patient Care STDS. 2008 Mar 28
Abstract
 
Discontinuation of highly active antiretroviral therapy leads to cryptococcal meningitis/choroiditis in
an AIDS patient.
Chronister CL.
Optometry. 2006 Sep;77(9):438-45
 Abstract

FULL-TEXT ARTICLE
A cryptic cause of cryptococcal meningitis.
Cheung MC, Rachlis AR, Shumak SL.
 CMAJ 2003 Feb 18;168(4):451-2
 Paper

  
     
  Papilloedema with peripapillary retinal haemorrhages in an acquired immunodeficiency
syndrome (AIDS) patient with cryptococcal meningitis.
Battu RR, Biswas J, Jayakumar N, et al .
Indian J Ophthalmol 2000 Mar;48(1):47-9
 Abstract		  
National Updates
       
Multinational

     Journal Papers, Abstracts, and Commentaries

  Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.
Rajasingham R, Smith RM, Park BJ,  et al
Lancet Infect Dis. 2017 May 5.
Abstract

Brazil
 
     Journal Papers, Abstracts, and Commentaries
 
  AIDS-associated central nervous system cryptococcosis: a Brazilian case study.
Pappalardo MC, Paschoal RC, Melhem MS. 
AIDS. 2007 Sep;21(14):1971-2
Abstract
 
India

     Journal Papers, Abstracts, and Commentaries
 
  FULL TEXT ARTICLE
Cryptococcal meningitis among HIV infected patients.
Manoharan G, Padmavathy BK, Vasanthi S, et al
Indian J Med Microbiol. 2001 Jul-Sep;19(3):157-8
Paper

 FULL TEXT ARTICLE
Cryptococcal meningitis in aids patients - A report of two cases.
Arora U, Aggarwal A.
Indian J Med Microbiol. 2001 Jul-Sep;19(3):153-4.
Paper
 
Guinea         

     Journal Papers, Abstracts, and Commentaries
 
  A clinical manifestation of AIDS with cryptococcal meningitis in Equatorial Guinea.
Wang W, Carm AR
 Trop Doct 2001 Oct;31(4):221-2
Abstract
 		  
Senegal     

     Journal Papers, Abstracts, and Commentaries
 
  Cryptococcal meningitis in Senegal: epidemiology, laboratory findings, therapeutic and outcome of cases diagnosed from 2004 to 2011.
 Sow D, Tine RC, Sylla K, et al
 Mycopathologia. 2013 Dec;176(5-6):443-9.
Abstract
 		  
Thailand       

     Journal Papers, Abstracts, and Commentaries
 
  Determinants of Mortality in a Combined Cohort of 501 Patients with HIV-associated Cryptococcal Meningitis: Implications for Improving Outcomes.
 Jarvis JN, Bicanic T, Loyse A,  et al
Clin Infect Dis. 2013 Dec 6
Abstract
 		  
Uganda    

     Journal Papers, Abstracts, and Commentaries
 
  Predictors of neurocognitive outcomes on antiretroviral therapy after cryptococcal meningitis: a prospective cohort study.
 Carlson RD, Rolfes MA, Birkenkamp KE,  et al
Metab Brain Dis. 2014 Jan 9.
Abstract
 		  
Zimbabwe 

     Journal Papers, Abstracts, and Commentaries
 
  Cryptococcus neoformans population diversity and clinical outcomes of HIV-associated cryptococcal meningitis patients in Zimbabwe.
Nyazika TK, Hagen F, Machiridza T, et al 
J Med Microbiol. 2016 Sep 13
Abstract		  
Videos
       
Meningitis in HIV
Christina M. Marra, MD

  Brain Main Page Main New/Newsworthy  Home Page

HIV- Associated Cryptococcal Meningitis/Meningoencephalitis