Medical Advocates
HIV Infection/Disease
  Hyperlipidemia and Associated
Disorders
 		  
Diagnosis
Treatment
ARV Drugs
Hypercholesterolemia
Hypertriglyceridemia


 
 
 
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Last Update: October 11, 2008
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Diagnosis
       

        Journal Papers, Abstracts, and Commentaries

 
Sustained improvement of dyslipidaemia in HAART-treated patients replacing stavudine with
tenofovir.
 Llibre JM, Domingo P, Palacios R, et al  
AIDS. 2006 Jun 26;20(10):1407-14.
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
 Improvement of Dyslipidemia during Different HAART Regimens: Tenofovir- versus Stavudine-
Containing Antiretroviral Combinations.
 Manfredi R.  
Clin Infect Dis. 2006 May 1;42(9):1345-7.
 Abstract

Differentiating hyperlipidaemia associated with antiretroviral therapy.
 Mauss S, Stechel J, Willers R, Schmutz G, et al
 AIDS 2003 Jan 24;17(2):189-94
 Abstract

  

Treatment
       

        Journal Papers, Abstracts, and Commentaries

 
A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected
subjects with hyperlipidaemia.
Townsend ML, Hollowell SB, Bhalodia J, et al 
I|nt J STD AIDS. 2007 Dec;18(12):851-5.
 Abstract
 
HIV and hyperlipidemia: current recommendations and treatment.
Capili B, Anastasi JK. 
Medsurg Nurs. 2006 Feb;15(1):14-9,
 Abstract
 
Randomized study of the safety and efficacy of fish oil (omega-3 Fatty Acid)
supplementation with dietary and exercise counseling for the treatment of
antiretroviral therapy-associated hypertriglyceridemia.
 Wohl DA, Tien HC, Busby M,et al 
Clin Infect Dis. 2005 Nov 15;41(10):1498-504.
 Abstract
 
Niacin in HIV-Infected Individuals with Hyperlipidemia Receiving Potent
Antiretroviral Therapy.
Gerber MT, Mondy KE, Yarasheski KE 
Clin Infect Dis. 2004 Aug 1;39(3):419-25.
 Abstract
 
Fenofibrate Is Effective in Treating Hypertriglyceridemia Associated with
HIV Lipodystrophy.
 Rao A, D'Amico S, Balasubramanyam A, Maldonado M. 
Am J Med Sci. 2004 Jun;327(6):3
 Abstract
 
HIV-associated and antiretroviral-induced hyperlipidaemia: an update.
Mauss S.
J HIV Ther. 2003 May;8(2):29-31.
Abstract

Treatment of hyperlipidemia in HIV-infected patients.
Geletko SM, ZuWallack AR.
Am J Health Syst Pharm 2001 Apr 1;58(7):607-14
Abstract    

Short-term exercise training improves body composition and hyperlipidaemia in
HIV-positive individuals with lipodystrophy.
Jones SP, Doran DA, Leatt PB, et al.
AIDS 2001 Oct 19;15(15):2049-51
 Abstract

  

Drugs
       
Lipid/Cholesterol Drugs

Ezetimibe

        Conference Reports, Abstracts, and Posters

  Ezetimibe, a Selective Inhibitor of Cholesterol Absorption, as a New Strategy for Treatment of
Hypercholesterolemia Secondary to Antiretroviral Therapy
E. NEGREDO, C. REY-JOLY, J. PUIG , et al 
(45 ICAAC)
 Abstract

Fluvastatin

        Journal Papers, Abstracts, and Commentaries

  Lipid Lowering Therapy with Fluvastatin and Pravastatin in Patients with HIV
Infection and Antiretroviral Therapy: Comparison of Efficacy and Interaction
with Indinavir.
Benesic A, Zilly M, Kluge F, et al
 Infection. 2004 Aug;32(4):229-33.
 Abstract

Pravastatin

        Journal Papers, Abstracts, and Commentaries

  Lipid Lowering Therapy with Fluvastatin and Pravastatin in Patients with HIV Infection
and Antiretroviral Therapy: Comparison of Efficacy and Interaction with Indinavir.
Benesic A, Zilly M, Kluge F, et al
 Infection. 2004 Aug;32(4):229-33.
 Abstract

Rosuvastatin

        Journal Papers, Abstracts, and Commentaries

  Rosuvastatin for the treatment of hyperlipidaemia in HIV-infected patients receiving protease
inhibitors: a pilot study.
Calza L, Colangeli V, Manfredi R, et al 
AIDS. 2005 Jul 1;19(10):1103-1105.
Abstract

ARV Drugs

General Reports

        Journal Papers, Abstracts, and Commentaries
 
 
Antiretroviral treatment for HIV infection/AIDS and the risk of developing hyperglycemia and
hyperlipidemia.
 Araujo PS, Ximenes RA, Lopes CF, et al
Rev Inst Med Trop Sao Paulo. 2007 Apr;49(2):73-78.
 Abstract
 
Hyperlipidaemia in patients with HIV-1 infection receiving highly active antiretroviral therapy:
epidemiology, pathogenesis, clinical course and management.
Calza L, Manfredi R, Chiodo F.et al
Int J Antimicrob Agents. 2003 Aug;22(2):89-99.
Abstract

HIV-infection, HAART and hyperlipidaemia
 Hirsch HH, Battegay M.
Dtsch Med Wochenschr 2003 May 9;128(19):1051-4
 Abstract

Severe hypertriglyceridaemia associated with human immunodeficiency virus and
highly active antiretroviral therapy.
Carling RS, Hextall R, DeSilva PA, Barth JH.
Ann Clin Biochem 2002 Jul;39(Pt 4):409-13
 Abstract

Hyperlipidemia in HIV-Positive Patients Receiving Antiretrovirals.
Segarra-Newnham M  
Ann Pharmacother 2002 Apr;36(4):592-5 
Abstract    

 

     Conference Reports, Abstracts, and Posters
 
  POSTER
 Determinants of Hyperlipidemia in ART-naive Subjects Treated with Trizivir,
Combivir/Nelfinavir, or Stavudine/Lamivudine
P Kumar, V Williams, K Tahima, et al
(11 CROI)
 PDF Poster     Abstract


Protease Inhibitors

        Journal Papers, Abstracts, and Commentaries
 
 
Incidence of hyperlipidaemia in a cohort of 212 HIV-infected patients receiving a
protease inhibitor-based antiretroviral therapy.
Calza L, Manfredi R, Farneti B, Chiodo F
Int J Antimicrob Agents. 2003 Jul;22(1):54-59.
Abstract

Effects of HIV protease inhibitor therapy on lipid metabolism.
Hui DY.
 Prog Lipid Res 2003 Mar;42(2):81-92
 Abstract

Hyperlipidemia in HIV-infected children treated with protease inhibitors: relevance for
cardiovascular diseases.
 Cheseaux JJ, Jotterand V, Aebi C, et al.
J Acquir Immune Defic Syndr 2002 Jul 1;30(3):288-93
 Abstract

Hyperlipidemia and insulin resistance are induced by protease inhibitors independent
of changes in body composition in patients with HIV infection.
Mulligan K, Grunfeld C, Tai VW, et al.
J Acquir Immune Defic Syndr 2000  Jan 1;23(1):35-43
 Abstract

  

       Conference Reports, Abstracts, and Posters

  POSTER
Predictive Factors of Hyperlipidemia in HIV-infected Subjects Receiving
Lopinavir/Ritonavir
M Bongiovanni, P Cicconi, S Landonio
 (11 CROI)
 PDF Poster      Abstract

Hypercholesterolemia
       

Journal Papers, Abstracts, and Commentaries

 
Impact of antiretroviral choice on hypercholesterolaemia events: the role of the nucleoside reverse
transcriptase inhibitor backbone.
 Jones R, Sawleshwarkar S, Michailidis C, et al
HIV Med. 2005 Nov;6(6):396-402.
 Abstract
 
Lipid Lowering Therapy with Fluvastatin and Pravastatin in Patients with HIV
Infection and Antiretroviral Therapy: Comparison of Efficacy and Interaction
with Indinavir.
 Benesic A, Zilly M, Kluge F, et al 
Infection. 2004 Aug;32(4):229-33.
 Abstract

Dietary advice with or without pravastatin for the management of
hypercholesterolaemia associated with protease inhibitor therapy.
Moyle GJ, Lloyd M, Reynolds B, Baldwin C, et al.
AIDS 2001 Aug 17;15(12):1503-8
 Abstract
 
           Conference Reports, Abstracts, and Posters
 
 
 

Ezetimibe, a Selective Inhibitor of Cholesterol Absorption, as a New Strategy for Treatment
of Hypercholesterolemia Secondary to Antiretroviral Therapy
E. NEGREDO, C. REY-JOLY, J. PUIG , et al
(45 ICAAC)
 Abstract

Hypertriglyceridemia

       

          Journal Papers, Abstracts, and Commentaries

 
Fish Oil and Fenofibrate for the Treatment of Hypertriglyceridemia in HIV-Infected Subjects
on Antiretroviral Therapy: Results of ACTG A5186.
 Gerber JG, Kitch DW, Fichtenbaum CJ, et al
J Acquir Immune Defic Syndr. 2007 Oct 25;
Abstract
 

Bezafibrate for the treatment of hypertriglyceridemia in HIV1-infected patients on highly
active antiretroviral therapy.
 Geraix J, Souza ME, Delatim FC, Pereira PC.
 Braz J Infect Dis. 2006 Jun;10(3):159-64.
 Abstract
   
  Minocycline- and tetracycline-induced hypertriglyceridemia in an HIV-seropositive patient
receiving combination antiretroviral therapy.
 Somani N, Bondy G, Crawford RI.
 Cutan Med Surg. 2006 May-Jun;10(3):142-6.
 Abstract
   
  A randomised controlled trial of omega-3 fatty acid supplementation for the treatment of
hypertriglyceridemia in HIV-infected males on highly active antiretroviral therapy.
 Carter VM, Woolley I, Jolley D, et al
 Sex Health. 2006 Dec;3(4):287-90
 Abstract
 
  Improved triglycerides and insulin sensitivity with 3 months of acipimox in human
immunodeficiency virus-infected patients with hypertriglyceridemia.
 Hadigan C, Liebau J, Torriani M, et al
 J Clin Endocrinol Metab. 2006 Nov;91(11):4438-44
 Abstract
 
  Associations between hypertriglyceridemia and serum ghrelin, adiponectin, and IL-18 levels
in HIV-infected patients.
 Falasca K, Manigrasso MR, Racciatti D, et al
 Ann Clin Lab Sci. 2006 Winter;36(1):59-66
 Abstract
 
  Randomized study of the safety and efficacy of fish oil (omega-3 fatty acid) supplementation
with dietary and exercise counseling for the treatment of antiretroviral therapy-associated
hypertriglyceridemia.
 Wohl DA, Tien HC, Busby M, et al
Clin Infect Dis. 2005 Nov 15;41(10):1498-504.
 Abstract
   
 
Improved Triglycerides and Insulin Sensitivity with 3 Months of Acipimox in HIV-infected Patients
with Hypertriglyceridemia.
Hadigan C, Liebau J, Torriani M, et al
J Clin Endocrinol Metab. 2006 Aug 29;
Abstract
 
Major Hypertriglyceridemia in HIV-Infected Patients on Antiretroviral Therapy:
A Role of the Personal and Family History.
Bollens D, Guiguet M, Tangre P, et al
Infection. 2004 Aug;32(4):217-21.
Abstract

Fenofibrate Is Effective in Treating Hypertriglyceridemia Associated with HIV
Lipodystrophy.
Rao A, D'Amico S, Balasubramanyam A, Maldonado M. 
Am J Med Sci. 2004 Jun;327(6):315-318.
Abstract
 
       Conference Reports, Abstracts, and Posters
 
  Lower prevalence of small, dense low-density lipoprotein (sd-LDL) in hypertriglyceridemic
HIV-infected patients than in non-HIV-infected subjects
 Trein A., Schnaitmann E, Richter W 
(4th IAS Conference)
 Abstracts

Treatment of Hypertriglyceridemia in HIV-infected Patients under HAART, by
(n-3)PolyunsaturatedFatty Acids: A Double-blind Randomized Prospective Trial
in 122 Patients
P De Truchis, M Kirstetter, A Perier, et al
 (12CROI)
 Abstract

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HIV/Hyperlipidemia