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HIV Infection/Disease
  Lipodystrophy
General Reports
 Pathogenesis
 Diagnostics
 Treatment
 Lipodystrophy-Syndrome
 Adipose Tissue Disorders
 Lipodystrophy-Related Disorders
 ART/HAART and Lipodystrophy
 Quality of Life


 
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Last Update: January 29, 2012
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General Reports
       
      Journal Papers, Abstracts, and Commentaries
 
 
Lipodystrophy in HIV patients: its challenges and management approaches.
 Singhania R, Kotler DP.
HIV AIDS (Auckl). 2011;3:135-43.
Abstract

Beneficial effects of physical activity in an HIV-infected woman with lipodystrophy:
a case report.
Mendes EL, Andaki AC, Brito CJ,  et al
J Med Case Reports. 2011 Sep 5;5(1):430.
Abstract

FULL-TEXT ARTICLE
 Lipodystrophy in HIV/AIDS patients with different levels of physical activity while on antiretroviral therapy.
Segatto AF, Freitas Junior IF,  et al
Rev Soc Bras Med Trop. 2011 Aug;44(4):420-4..
 Paper

The Effect of polymorphisms in candidate genes on the Long-Term Risk of Lipodystrophy
and Dyslipidemia in HIV-infected Caucasians Starting Antiretroviral Therapy.
Marzocchetti A, Schwarz J, DI Giambenedetto S,   et al
AIDS Res Hum Retroviruses. 2011 May 20.
Abstract

HIV-associated lipodystrophy: from fat injury to premature aging.
Caron-Debarle M, Lagathu C, Boccara F,  et al 
Trends Mol Med. 2010 Apr 16
Abstract

The Association of Lipodystrophy and Oxidative Stress Biomarkers in HIV-Infected Men.
Vassimon HS, Deminice R, Machado AA,  et al  
Curr HIV Res. 2010 Mar 19
Abstract

Lipodystrophy - a sign for metabolic syndrome in patients of the HIV-HEART study.
Potthoff A, Brockmeyer NH, Gelbrich G, et al
J Dtsch Dermatol Ges. . [Epub ahead of print]
Abstract

Drug-induced lipotoxicity: lipodystrophy associated with HIV-1-infection and antiretroviral treatment.
Villarroya F, Domingo P, Giralt M.
 Biochim Biophys Acta. 2009 Sep 29.
Abstract

Dietary intake in HIV-infected men with lipodystrophy: relationships with body composition,
visceral fat, lipid, glucose and adipokine metabolism.
Samaras K, Wand H, Law M, et al 
Curr HIV Res. 2009 Jul;7(4):454-61
Abstract

Lipodystrophy and Metabolic Disorders in HIV-1-Infected Adults on 4- to 9-Year Antiretroviral
Therapy in Senegal: A Case-Control Study.
Mercier S, Gueye NF, Cournil A, et al 
J Acquir Immune Defic Syndr. 2009 Mar 31
Abstract
 
Relationship between polymerase gamma (POLG) polymorphisms and antiretroviral therapy-induced
lipodystrophy in HIV-1 infected patients: a case-control study.
Chiappini F, Teicher E, Saffroy R, et al 
Curr HIV Res. 2009 Mar;7(2):244-53
Abstract
 

A study of HIV-related lipodystrophy syndrome in 55 HIV-infected Chinese adult patients.
Zhang L, Li M, Tao MM, et al|
 Zhonghua Nei Ke Za Zhi. 2009 Feb;48(2):118-21.
Abstract

Alcohol consumption and lipodystrophy in HIV-infected adults with alcohol problems.
Cheng DM, Libman H, Bridden C, Saitz R, Samet JH. 
Alcohol. 2009 Feb;43(1):65-71
Abstract
 
Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients:
Alteration of the PPARgamma-Dependent Pathways.
Caron M, Vigouroux C, Bastard JP, Capeau J.
 PPAR Res. 2009;2009:507141.
Abstract
 
FULL TEXT PDF ARTICLE
The impact of HIV-associated lipodystrophy on healthcare utilization and costs.
Huang JS, Becerra K, Fernandez S, et al
 AIDS Res Ther. 2008 Jul 1;5(1):14.
 Paper
 
HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options.
Mallewa JE, Wilkins E, Vilar J,  et al
 J Antimicrob Chemother. 2008 Jun 18.
Abstract
 
Heel pain and HIV-associated lipodystrophy: a report of two cases.
Stupar M, Tibbles A
JCCA J Can Chiropr Assoc. 2008 Jun;52(2):103-109.
Abstract
 
Lipodystrophy in HIV 1-infected patients: lessons for obesity research.
Villarroya F, Domingo P, Giralt M.
 Int J Obes (Lond). 2007 Jul 24;
Abstract
 
Circulating sex hormones and gene expression of subcutaneous adipose tissue oestrogen
and alpha-adrenergic receptors in HIV-lipodystrophy: implications for fat distribution.
Andersen O, Pedersen SB, Svenstrup B, et al
 Clin Endocrinol (Oxf). 2007 May 24;
 Abstract
 
Evaluation of the HIV lipodystrophy case definition in a placebo-controlled, 144-week study in
antiretroviral-naive adults.
Law M, Puls R, Cheng AK, et al  
Antivir Ther. 2006;11(2):179-86.
 Abstract
 
Glucose-stimulated prehepatic insulin secretion is associated with circulating alanine,
triglyceride, |glucagon, lactate and TNF-alpha in patients with HIV-lipodystrophy.
Haugaard S, Andersen O, Pedersen S, et al 
HIV Med. 2006 Apr;7(3):163-72.
 Abstract
 
Lipodystrophy and Dyslipidemia Among Patients Taking First-Line, World Health Organization-
Recommended Highly Active Antiretroviral Therapy Regimens in Western India.
 Pujari SN, Dravid A, Naik E, et al
J Acquir Immune Defic Syndr. 2005 Jun 1;39(2):199-202
 Abstract
 
HIV-Associated Cervicodorsal Lipodystrophy: Etiology and Management.
 Gold DR, Annino DJ, Jr  .Laryngoscope. 2005 May;115(5):791-5
 Abstract
 
Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients
with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells.
 Haugaard SB, Andersen O, Dela F. 
Eur J Endocrinol. 2005 Jan;152(1):103-12.
 Abstract
 
Lipodystrophy associated with highly active anti-retroviral therapy for HIV
infection: the adipocyte as a target of anti-retroviral-induced mitochondrial
toxicity.
 Villarroya F, Domingo P, Giralt M. 
Trends Pharmacol Sci. 2005 Feb;26(2):88-93
 Abstract
 
HIV-related lipodystrophy and related factors.
Tershakovec AM, Frank I, Rader D.
Atherosclerosis. 2004 May;174(1):1-10.
 Abstract
 
Risk factors for lipodystrophy in the CISAI cohort.
Bonfanti P, Gulisano C, Ricci E, et al 
Biomed Pharmacother. 2003 Nov;57(9):422-7.
 Abstract
 
AIDS-related Insulin Resistance and Lipodystrophy Syndrome.
Kino T, Chrousos GP.
Curr Drug Targets Immune Endocr Metabol Disord 2003 Jun;3(2):111-7
 Abstract

FULL-TEXT ARTICLE
Body habitus changes related to lipodystrophy.
Sattler F.
Clin Infect Dis 2003 Apr 1;36(Suppl 2):S84-90
 Paper

An objective case definition of lipodystrophy in HIV-infected adults: a case-
control study.
Carr A. 
Lancet 2003 Mar 1;361(9359):726-35
 Abstract

Lipodystrophy in Human Immunodeficiency Virus-Infected Patients.
Chen D, Misra A, Garg A. et al
J Clin Endocrinol Metab. 2002 Nov;87(11):4845-56.
 Abstract

Lipodystrophy in a cohort of human immunodeficiency virus-infected
asian patients: prevalence, associated factors, and psychological impact.
Paton NI, Earnest A, Ng YM, Karim F, Aboulhab J.
Clin Infect Dis 2002 Nov 15;35(10):1244-9
 Abstract

Metabolic basis of HIV-lipodystrophy syndrome.
Sekhar RV, Jahoor F, White AC, et al.
Am J Physiol Endocrinol Metab 2002Aug;283(2):E332-7
 Abstract

Self-reported signs of lipodystrophy by persons living with HIV infection.
Dreezen C, Schrooten W, de Mey I, et al.
Int J STD AIDS 2002 Jun;13(6):393-8
 Abstract

Does Race Protect an Oriental Population From Developing Lipodystrophy
in HIV-infected Individuals on HAART?
Chang KH, Kim JM, Song YG, et al.
J.Infect 2002 Feb;44(1):33-8
 Abstract

Nutritional status, symptoms experienced and general state of health in HIV-
infected patients.
Karlsson A, Nordstrom G.
J Clin Nurs 2001 Sep;10(5):609-17
Abstract

  

     Conference Reports, Abstracts, and Posters

 
POSTER
Incidence of Lipodystrophy and Metabolic Syndrome after the Initiation of Combined ART in
Sub-Saharan cART-naive Patients
S Eholie, K Lacombe, L Denoeud, et al
(15 CROI)
 PDF Poster    Abstract
 
POSTER
Relationship between Polymerase Gamma Polymorphisms and ART-induced Lipodystrophy
in HIV-infected Patients: A Case-Control Study
F Chiappini, E Teicher, D Vittecoq, A Lemoine
(15 CROI)
 PDF Poster   Abstract
 
Upregulation of the mitochondrial PRSS15/LON during lipodistrophy: ex vivo and in vitro
detection
Pinti M, Gibellini L, Guaraldi G, et al
 (4th IAS Conference)
 Abstract

Pathogenesis
       

         Journal Papers, Abstracts, and Commentaries

 
The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated Lipodystrophy: Cellular
Mechanisms and Clinical Implications.
 Flint OP, Noor MA, Hruz PW, et al 
Toxicol Pathol. 2009 Jan 26.
 Abstract
 
Pathogenesis of lipodystrophy and metabolic syndromes associated with HIV infection
 Munoz-Sanz A, Rodriguez-Vidigal FF, Domingo P.
Med Clin (Barc). 2006 Sep 30;127(12):465-74.
 Abstract

Do oestrogen receptors play a role in the pathogenesis of HIV-associated
lipodystrophy?
 Barzon L, Zamboni M, Pacenti M, et al   
AIDS. 2005 Mar 25;19(5):531-3.
Abstract

           Conference Reports, Abstracts, and Posters

  POSTER
The Effect of Polymorphism of the MDR-1 Gene on the Long-term Risk of Lipodystrophy
and Dyslipidemia in HIV-infected Patients Starting ART
A De Luca, S Di Giambenedetto, J Schwarz, et al 
(13 CROI)
PDF Poster     Abstract
Lipodystrophy-Related Disorders
       

         Journal Papers, Abstracts, and Commentaries

 
"Bullfrog Neck," a Unique Morphologic Trait in HIV Lipodystrophy: Case Series and
Review of the Literature.
Tierney EP, Hanke CW.
Arch Dermatol. 2010 Nov;146(11):1279-1282.
 Abstract

In the lipodystrophy associated with highly active antiretroviral therapy,
pseudo-Cushing's syndrome is associated with increased regeneration of
cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue.
Sutinen J, Kannisto K, Korsheninnikova E, et al 
Diabetologia. 2004 Sep 29
 Abstract
 
Lipodystrophy in human immunodeficiency virus patients impairs insulin action
and induces defects in beta-cell function.
Andersen O, Haugaard SB, Andersen UB, et al
Metabolism. 2003 Oct;52(10):1343-53
 Abstract
 
Elevated blood pressure in subjects with lipodystrophy.
Sattler FR, Qian D, Louie S, et al.
AIDS 2001Oct 19;15(15):2001-10
Abstract
 
Antiretroviral Therapy and Lipodystrophy
ART/HAART General Protease Inhibitors    

ART/HAART General

        Journal Papers, Abstracts, and Commentaries

 
Lipodystrophies related to antiretroviral treatment of HIV infection
Capeau J, Caron M, Vigouroux C,et al
Med Sci (Paris). 2006 May;22(5):531-536.
 Abstract

Factors related to lipodystrophy and metabolic alterations in patients with human
immunodeficiency virus infection receiving highly active antiretroviral therapy.
Saves M, Raffi F, Capeau J, et al.
Clin Infect Dis 2002 May 15;34(10):1396-405
 Abstract

Effect of highly active antiretroviral therapy on fat, lean, and bone mass in HIV-
seropositive men and women.
McDermott AY, Shevitz A, Knox T, et al.
Am J Clin Nutr 2001 Nov;74(5):679-86
 Abstract

 
Antiretroviral treatment simplification with nevirapine in protease inhibitor-experienced
patients with hiv-associated lipodystrophy:1-year prospective follow-up of a multicenter,
randomized, controlled study.
Ruiz L, Negredo E, Domingo P, Paredes R, et al.
J Acquir Immune Defic Syndr 2001 Jul 1;27(3):229-36
 Abstract
 

 
           Conference Reports, Abstracts, and Posters
 
  "Lipodystrophy" is not what it used to be: data from the Swiss HIV cohort study
 Nguyen A, Bernasconi E, Battegay M, et al
 (4th IAS Conference)
 Abstract

Protease Inhibitors

        Journal Papers, Abstracts, and Commentaries

 
HIV protease inhibitor substitution in patients with lipodystrophy: a randomized,
controlled, open-label, multicentre study.
Carr A, Hudson J, Chuah J, Mallal S, et al.
AIDS 2001 Sep 28;15(14):1811-1822
 Abstract

FULL-TEXT ARTICLE
Inhibition of Adipocyte Differentiation by HIV Protease Inhibitors
Zhang B,  MacNaul,  Szalkowski D,et al.
J Clin Endocrinol Metab 1999 84: 4274-4277
 Paper

  
Quality of Life
Also refer to Quality of Life with Lipodystrophy Syndrome      

       Journal Papers, Abstracts, and Commentaries

 
Lipodystrophy and quality of life in HIV: Symptom management issues.
 Nicholas PK, Kirksey KM, Corless IB, et al   
Appl Nurs Res. 2005 Feb;18(1):55-8.
 Abstract

Factors Associated with Severe Impact of Lipodystrophy on the Quality
of Life of Patients Infected with HIV-1.
Blanch J, Rousaud A, Martinez E, et al
Clin Infect Dis. 2004 May 15;38(10):1464-70
 Abstract
 

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HIV-Associated Lipodystrophy