Medical Advocates

HCV Infection/Disease
  Investigational Drugs  
General Reports
Alisporivir
Cannabinoids
Anti-tumor Necrosis Factor-alpha
HEP1
Levovirin
Resiquimod

Telaprevir
Thymosin alpha1
Viramidine
VX-950



 





 

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Last Update:  February 06, 2010
 
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General Reports
 

      Conference Reports, Abstracts, and Posters
 

  CONFERENCE PRESENTATION
Future Therapy of Hepatitis C
McHutchison JG
[NIH Consensus Development Conference on  Management of Hepatitis C: 2002]

Report

Alisporivir
 

      Journal Papers, Abstracts, and Commentaries
 
  Alisporivir, a cyclosporin derivative that selectively inhibits cyclophilin,
for the treatment of HCV infection.
Watashi K.
Curr Opin Investig Drug
s
. 2010 Feb;11(2):213-24.

Abstract

Anti-tumor Necrosis Factor-alpha
 

      Journal Papers, Abstracts, and Commentaries
 
  Etanercept treatment for three months is safe in patients with rheumatological
manifestations associated with hepatitis C virus.

Marotte H, Fontanges E, Bailly F, et al   
Rheumatology
(Oxford). 2006 May 23;

Abstract

Cannabinoids
 

      Journal Papers, Abstracts, and Commentaries
 
  Reefer madness? Assessing the effects of cannabinoids with a less jaundiced eye
Friedman SL.
J Hepatol.
2006 Oct 30;

Abstract

HEP1
 

     Journal Papers, Abstracts, and Commentaries

  Treatment of hepatitis C virus infection with human ezrin peptide one (HEP1) in HIV infected
patients.

Salamov G, Holms R, Bessler WG, Ataullakhanov R.

Arzneimittelforschung. 2007;57(7):497-504.
Abstract

Levovirin
 

      Journal Papers, Abstracts, and Commentaries
 
  Prospects for hepatitis C virus therapeutics: levovirin and viramidine as improved derivatives
of ribavirin.

Watson J.
Curr Opin Investig Drugs 2002 May;3(5):680-3  

Abstract

Resiquimod
 

      Journal Papers, Abstracts, and Commentaries
 
  Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled,
double-blind phase IIa studies

Pockros PJ, Guyader D, Patton H, Tong MJ, et al
J Hepatol. 2007 May 4;

Abstract

Telaprevir
 

   Journal Papers, Abstracts, and Commentaries
 
  The efficacy and safety of telaprevir - a new protease inhibitor against hepatitis C virus.
Gentile I, Carleo MA, Borgia F,
et al
Expert Opin Investig Drugs
. 2010 Jan;19(1):151-9.
Abstract
 
Highly sensitive determination of HCV protease inhibitors boceprevir (SCH 503034) and t
elaprevir (VX 950) in human plasma by LC-MS/MS.

Farnik H, El-Duweik J, Welsch C,

J Chromatogr B Analyt Technol Biomed Life Sci
. 2009 Dec 1;877(31):4001
Abstract
 
Sustained virological response in a patient with chronic hepatitis C treated by monotherapy
with the NS3-4A protease inhibitor telaprevir.

Suzuki F, Suzuki Y, Akuta N,
et al
Clin Virol
. 2009 Oct 24.
Abstract
 
Characterization of resistance to the protease inhibitor boceprevir in hepatitis C
virus-infected patients.

Susser S, Welsch C, Wang Y, et al

Hepatology
. 2009 Dec;50(6):1709-18.
Abstract
 
Telaprevir: hope on the horizon, getting closer.
Weisberg IS, Jacobson IM.

Clin Liver Dis
. 2009 Aug;13(3):441-52
Abstract
 
Rapid loss of hepatitis C virus genotype 1b from serum in patients receiving a triple treatment
with telaprevir (MP-424), pegylated interferon and ribavirin for 12 weeks.

Suzuki F, Akuta N, Suzuki Y,
et al
Hepatol Res
. 2009 Nov;39(11):1056-63
Abstract

FULL=TEXT ARTICLE
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection.
Hézode C, Forestier N, Dusheiko G, et al
N Engl J Med
. 2009 Apr 30;360(18):1839-50
Paper

Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection.
McHutchison JG, Everson GT, Gordon SC, et al
N Engl J Med
. 2009 Apr 30;360(18):1827-38
Abstract
 
Telaprevir: a promising protease inhibitor for the treatment of hepatitis C virus infection.
Gentile I, Viola C, Borgia F, Castaldo G, Borgia G.
Curr Med Chem. 2009;16(9):1115-21.

Abstract

 

 


Thymosin alpha1
 

      Journal Papers, Abstracts, and Commentaries
 
  Thymosin alpha1
Billich A.
Curr Opin Investig Drugs 2002 May;3(5):698-707

Abstract   

VX-950
 

      Journal Papers, Abstracts, and Commentaries
 
  Prospects for hepatitis C virus therapeutics: levovirin and viramidine as improved
derivatives of ribavirin.

Watson J.
Curr Opin Investig Drugs 2002 May;3(5):680-3  
Abstract

Viramidine
 

      Journal Papers, Abstracts, and Commentaries
 
 
A phase III study of the safety and efficacy of viramidine versus ribavirin in treatment-naïve
patients with chronic hepatitis C: ViSER1 results.

Benhamou Y, Afdhal NH, Nelson DR, et al
Hepatology. 2009 May 11
Abstract

Rapid Decline of Viral RNA in Hepatitis C Patients Treated With VX-950: A Phase Ib,
Placebo-Controlled, Randomized Study.
Reesink HW, Zeuzem S, Weegink CJ, et al
Gastroenterology
. 2006 Oct;131(4):997-1002.
Abstract


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