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Amantadine Hydrochloride (Symadine, Symmetrel)
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Combination Therapies







 
 
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Last Update:  February 12, 2015
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General Reports
               
     Journal Abstracts, Posters, and Commentaries
 
 
Effect of Amantadine on Depressive Symptoms in Chronic Hepatitis C Patients Treated with
Pegylated Interferon:  Randomized, Controlled Pilot Study.
Quarantini LC, Miranda-Scippa A, Schinoni MI, et al
Clin Neuropharmacol. 2006 May/June;29(3):138-143.
 Abstract

Evaluation of amantadine in chronic hepatitis C: a meta-analysis.
Deltenre P, Henrion J, Canva V, et al 
J Hepatol. 2004 Sep;41(3):462-73
 Abstract
 
Amantadine therapy for chronic hepatitis C.
Smith JP, Riley TR 3rd, Devenyi A,et al
J Gen Intern Med. 2004 Jun;19(6):662-8.
 Abstract
 
Role of amantadine and other adjuvant therapies in the treatment of hepatitis C.
Brillanti S.
Semin Liver Dis. 2004 May;24 Suppl 2:89-95.
 Abstract
Dosage Studies
               
     Journal Abstracts, Posters, and Commentaries
 
  Amantadine therapy for chronic hepatitis C: a dose escalation study.
 Smith JP, Riley TR 3rd, Bingaman S, Mauger DT.
Am J Gastroenterol. 2004 Jun;99(6):1099-104.
 Abstract
Combination Therapies
               
     Journal Abstracts, Posters, and Commentaries
 
 
Placebo-controlled trial of 400 mg amantadine combined with peginterferon alfa-2a and ribavirin for
48 weeks in chronic hepatitis C virus-1 infection.
 von Wagner M, Hofmann WP, Teuber G,  et al  
Hepatology. 2008 Nov;48(5):1404-11
 Abstract
 
Placebo-controlled trial of 400 mg amantadine combined with peginterferon alfa-2a and ribavirin for 48 weeks
in chronic hepatitis C virus-1 infection.
von Wagner M, Hofmann WP, Teuber G, et al
Hepatology. 2008 Jun 19.
Abstract
 
Long-Term Treatment with the Combination of Amantadine and Ribavirin in Hepatitis C
Nonresponders. A Case Series.
 Riley TR 3rd, Taheri MR.
Dig Dis Sci. 2007 Mar 31;
 Abstract
 
A randomized, controlled trial of triple antiviral therapy as initial treatment of chronic hepatitis C
in HIV-infected patients.
 Puoti M, Zanini B, Quinzan GP, Ravasio L, et al.  
 J Hepatol. 2004 Aug 1;41(2):312-318.
 Abstract
 
Combination therapy with amantadine and interferon in naive patients with chronic hepatitis C:
meta-analysis of individual patient data from six clinical trials.
Mangia A, Leandro G, Helbling B,et al
J Hepatol. 2004 Mar;40(3):478-83.
Abstract
 
Interferon alfa2a induction therapy in combination with ribavirin and amantadine for the treatment of
naive patients with chronic HCV infection.
Engler S, Flechtenmacher C, Wiedemann KH, et al
J Viral Hepat. 2004 Jan;11(1):60-8
 Abstract
 
A pilot study of combination therapy with initial high-dose interferon and amantadine hydrochloride
for patients with chronic hepatitis C with the genotype 1b virus.
Uyama H, Enomoto H, Kishima Y, et al
Hepatogastroenterology. 2003 Nov-Dec;50(54):2112-6.
 Abstract
 
Combination of interferon alfa-2a and amantadine does not improve the efficacy of interferon therapy
in patients with chronic hepatitis C.
Yang SS, Tu TC, Wu CH, Chen DS.
Hepatogastroenterology. 2003 Sep-Oct;50(53):1575-8.
 Abstract
 
Interferon, ribavirin and amantadine in prior nonresponders to interferon and ribavirin therapy with
chronic hepatitis C (genotype 1)
Olveira A, Serrano C, Erdozain JC,
Gastroenterol Hepatol. 2003 Oct;26(8):465-8
 Abstract
 
A randomised, open label, controlled trial on the effect of interferon plus amantadine compared
with interferon alone for treatment of chronic hepatitis C.
Baisini O, Gracielle Pigozzi M, et al
Hepatol Res. 2003 Jul;26(3):167-173.
 Abstract
 
Triple therapy with amantadine in treatment-naive patients with chronic hepatitis C: a
placebo-controlled trial.
Berg T, Kronenberger B, Hinrichsen H,et al
Hepatology. 2003 Jun;37(6):1359-67.
 Abstract
 
Chronic hepatitis C patients with a post-treatment virological relapse re-treated with an induction
dose of 18 MU interferon-alpha in combination with ribavirin and amantadine: a two-arm
randomized pilot study.
Weegink CJ, Sentjens RE, Beld MG
J Viral Hepat. 2003 May;10(3):174-82
 Abstract

Triple therapy with amantadine in treatment-naive patients with chronic  hepatitis C:
A placebo-controlled trial.
 Berg T, Kronenberger B, Hinrichsen H, et al.
 Hepatology 2003 Jun;37(6):1359-1367
 Abstract
 
  Chronic hepatitis C patients with a post-treatment virological relapse re-treated with an
induction dose of 18 MU interferon-alpha in combination with ribavirin and amantadine:
a two-arm randomized pilot study.
 Weegink CJ, Sentjens RE, Beld MG,  et al
 Viral Hepat 2003 May;10(3):174-82
 Abstract

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