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  Genotype Testing for HIV Drug
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Last Update:  January 29, 2011
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General Reports
       
     Journal Papers, Abstracts, and Commentaries
 
 
The long-term benefits of genotypic resistance testing in patients with extensive prior antiretroviral
therapy: a model-based approach.
Yazdanpanah Y, Vray M, Meynard J, Losina E, et al
HIV Med. 2007 Oct;8(7):439-50.
Abstract
 
Clinical Utility of HIV Standard Genotyping among Antiretroviral-Naive Individuals with
Unknown Duration of Infection.
Smith D,Moini N, Pesano R, et al
Clin Infect Dis. 2007 Feb 1;44(3):456-8.
 Abstract
 
Web Resources for HIV Type 1 Genotypic-Resistance Test Interpretation.
Liu TF, Shafer RW.
Clin Infect Dis. 2006 Jun 1;42(11):1608-1618.
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Successful use of genotypic resistance testing in HIV-1-infected individuals with detectable viraemia
between 50 and 1000 copies/ml.
Waters L, Mandalia S, Asboe D. 
AIDS. 2006 Mar 21;20(5):778-9.
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Utilization and Access to Antiretroviral Genotypic Resistance Testing and Results Within the
US Department of Veterans Affairs.
Goetz MB, Holodniy M, Poulton JS, et al
J Acquir Immune Defic Syndr. 2006 Jan 1;41(1):59-62
 Abstract

Correlation between rules-based interpretation and virtual phenotype interpretation of
HIV-1 genotypes for predicting drug resistance in HIV-infected individuals.
Gallego O, Martin-Carbonero L, Aguero J, et al
 J Virol Methods. 2004 Oct;121(1):115-8.
 Abstract
 
Genotypic Analysis of HIV-1 Drug Resistance at the Limit of Detection: Virus Production
without Evolution in Treated Adults with Undetectable HIV Loads.
Kieffer TL, Finucane MM, Nettles RE, et al 
J Infect Dis. 2004 Apr 15;189(8):1452-65.
 Abstract
 
Variable prediction of antiretroviral treatment outcome by different systems for interpreting
genotypic human immunodeficiency virus type 1 drug resistance.
De Luca A, Cingolani A, Di Giambenedetto S, et al
J Infect Dis. 2003 Jun 15;187(12):1934-43.
 Abstract
 
Performance Characteristics of Human Immunodeficiency Virus Type 1(HIV-1)
Genotyping Systems in Sequence-Based Analysis of Subtypes Other than HIV-1
Subtype B.
 Jagodzinski LL, Cooley JD, Weber M, Michael NL .
 J Clin Microbiol 2003 Mar;41(3):998-1003
 Abstract
 
A genotypic drug resistance interpretation algorithm that significantly predicts
therapy response in HIV-1-infected patients
 Van Laethem K, De Luca A, Antinori A, et al.
Antivir Ther 2002 Jun;7(2):123-9
Abstract
 
Genotypic testing for human immunodeficiency virus type 1 drug resistance.
Shafer RW.
Clin Microbiol Rev 2002 Apr;15(2):247-77
 Abstract
 

     Conference Reports, Abstracts, and Posters
 
             17th CROI
 
  POSTER
 Evaluation of an Affordable Assay for Drug-resistance Genotyping of All Major HIV-1
Subtypes
 S Aitken, A Kliphuis, C Wallis, et al
PDF Poster          Abstract
 
POSTER
 Toward Optimal ART for HIV-2 Infection: Can Genotypic and Phenotypic Drug Resistance
Testing Help Guide Therapy in HIV-2?
R Smith, S Ba, S Hawes,  et al
PDF Poster     Abstract

        XII International HIV Drug Resistance Workshop

  PDF POSTER
 Clinician knowledge and attitudes towards genotypic testing
 C Salama, et al.
H Walter, M Helm, R Ehret, er al.
PDF Poster
 
POSTER
 Clinically relevant interpretation of genotype for resistance to ritonavir (100 mg twice daily) plus
saquinavir (800 mg twice daily) in HIV-1-infected protease inhibitor-experienced patients
 V Calvez, et al
 Poster

        1st European HIV Drug Resistance Workshop

  PDF POSTER
 The Prognostic Value to Predict Virological Outcomes of 14 Distinct Systems Used to Interpret
 the Results of Genotypic HIV-1 Drug Resistance Testing in Untreated Patients
A De Luca, A Cozzi-Lepri, CF Perno, et al 
PDF Poster
Efficacy
       

     Journal Papers, Abstracts, and Commentaries

 
GENOPHAR: a randomized study of plasma drug measurements in association with
genotypic resistance testing and expert advice to optimize therapy in patients failing
antiretroviral therapy.
Bossi P, Peytavin G, Ait-Mohand H, Delaugerre C, et al 
HIV Med. 2004 Sep;5(5):352-9.
Abstract
 
Sources and Magnitude of Intralaboratory Variability in a Sequence-Based Genotypic
Assay for Human Immunodeficiency Virus Type 1 Drug Resistance.
Galli RA, Sattha B, Wynhoven B,  et al.
J Clin Microbiol. 2003 Jul;41(7):2900-2907
 Abstract

Performance Characteristics of the TRUGENE HIV-1 Genotyping Kit and the Opengene
DNA Sequencing System.
Kuritzkes DR, Grant RM, Feorino P, et al :
J Clin Microbiol 2003 Apr;41(4):1594-1599
 Abstract

Accuracy of the TRUGENE HIV-1 Genotyping Kit.
Grant RM, Kuritzkes DR, Johnson VA, et al :
J Clin Microbiol 2003 Apr;41(4):1586-1593
 Abstract

Genotypic inhibitory quotient as predictor of virological response to ritonavir-amprenavir in
human immunodeficiency virus type 1 protease inhibitor-experienced patients.
Marcelin AG, Lamotte C, Delaugerre C, et al.
 Antimicrob Agents Chemother 2003 Feb;47(2):594-600
 Abstract

Discrepant results in the interpretation of HIV-1 drug-resistance genotypic data among widely
used algorithms.
Kijak GH, Rubio AE, Pampuro SE 
HIV Med 2003 Jan;4(1):72-78
 Abstract

Study of the impact of HIV genotypic drug resistance testing on therapy efficacy.
Van Vaerenbergh K.  Verh K
Acad Geneeskd Belg 2001;63(5):447-73
Abstract

Application of HIV-1 genotypic-resistance testing prevents the evolution of further resistance
mutations in heavily  pretreated patients.
Zollner B, Feucht HH, Weitner L, et al,
J Clin Virol 2001 Apr;21(1):37-45
Abstract

Use of genotypic resistance testing to guide hiv therapy: clinical impact and cost-effectiveness.
Weinstein MC, Goldie SJ, Losina E, et al  
Ann Intern Med 2001 Mar 20;134(6):440-50
Abstract   

 
Interpretation
       

       Journal Papers, Abstracts, and Commentaries

 
Algorithms for the interpretation of HIV-1 genotypic drug resistance information.
Vercauteren J, Vandamme AM.   
Antiviral Res. 2006 May 30;
 Abstract
 
Accuracy, precision, and consistency of expert HIV type 1 genotype interpretation:
an international comparison (The GUESS Study).
Zolopa AR, Lazzeroni LC, Rinehart A, Vezinet  
Clin Infect Dis. 2005 Jul 1;41(1):9
 Abstract

How does expert advice impact genotypic resistance testing in clinical practice?
 Badri SM, Adeyemi OM, Max BE 
Clin Infect Dis. 2003 Sep 1;37(5):708-13. .
 Abstract
Genotype/Phenotype Comparison Studies
       

     Journal Papers, Abstracts, and Commentaries

  HIV-1 genotyping: comparison of two commercially available assays.
Sturmer M, Berger A, Preiser W.et al  
Expert Rev Mol Diagn. 2004 May;4(3):281-91.
 Abstract

     Conference Reports, Abstracts, and Posters

          1st European HIV Drug Resistance Workshop

  POSTER
 Discrepant results between antiretroviral resistance mutations patterns by genotypic|
analysis (Stanford HIV-SEQ program) and virtual phenotype (VircoNET)
Pérez-Alvarez L, Carmona R, Muñoz M. et al 
PDF Poster

          9th Conference on Retroviruses and Opportunistic Infections

 

POSTER
 CREST-- A Randomised Comparison of  Resistance Test Platforms: Genotype and
Virtual Phenotype
C. Workman, G. Hales, P. McKenna for the CREST Study Group
PDF Poster     Abstract

POSTER
Head-to-Head Comparison of Widely Used HIV-1 Drug Resistance Algorithms: RetroGram
and VGI-TRUGENE HIV-1
C Torti , E Quiros-Roldan  , CAB Boucher, et al.
PDF Poster     Abstrat

Genotype, Phenotype, and Virtual Phenotype at Baseline and at Failure in Naïve
Patients Included in a Randomized Trial( Rescombine Study) .
E. Ferrer, D. Podzamczer, M. Arnedo,et al.
 Abstract

  
Genotype Comparison  Studies
       

    Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT ARTICLE
 Comparison of HIV-1 Genotypic Resistance Test Interpretation Systems in Predicting
Virological Outcomes Over Time.
Frentz D, Boucher CA, Assel M, De Luca A, et al  
PLoS One. 2010 Jul 9;5(7):e11505
 Paper

Performance of two commercially available sequence-based HIV-1 genotyping systems
for the detection of drug resistance against HIV type 1 group M subtypes.
 Beddows S, Galpin S, Kazmi SH, et al
J Med Virol 2003 Jul;70(3):337-42
 Abstract

Comparison of capillary electrophoresis sequencing with the new CEQ 2000 DNA Analysis
System to conventional gel based systems for HIV drug resistance
analysis
Merel P, Pellegrin I, Garrigue I, et al.
J Virol Methods 2001 Oct;98(1):9-16
Abstract
Human immunodeficiency virus type 1 drug resistance testing: a comparison of three
sequence-based methods.
Erali M, Page S, Reimer LG, Hillyard DR.
J Clin Microbiol 2001 Jun;39(6):2157-65
Abstract

  

     Conference Reports, Abstracts, and Posters

          XII International HIV Drug Resistance Workshop

  POSTER
 Clinically relevant interpretation of genotype for resistance to ritonavir (100 mg twice daily)
plus saquinavir (800 mg twice daily) in HIV-1-infected protease inhibitor-experienced patients
 V Calvez, et al
 Poster
 
POSTER
 Correlation between Interpreted Genotype and Virtual Phenotype for predicting drug
resistance in HIV-1
 O Gallego, et al.
 Poster
Cost/Benefit/Effectiveness Studies
       

     Journal Papers, Abstracts, and Commentaries

  Economic evaluation of drug resistance genotyping for the adaptation of treatment in
HIV-infected patients in the VIRADAPT study.
Chaix C, Grenier-Sennelier C, Clevenbergh  et al.
J Acquir Immune Defic Syndr 2000 Jul 1;24(3):227-31
Abstract     

HIV-1 drug resistance genotyping. A review of clinical and economic issues.
Chaix-Couturier C, Holtzer C, Phillips KA, et al.
Pharmacoeconomics 2000 Nov;18(5):425-33
Abstract

  
Select Genotype Outcome Studies
       

     Journal Papers, Abstracts, and Commentaries  

 
Clinically relevant interpretation of genotype for resistance to abacavir.
 Brun-Vezinet F, Descamps D, Ruffault A, et al  
 AIDS. 2003 Aug 15;17(12):1795-1802
 Abstract

Comparison of the efficacy, safety and predictive value of HIV genotyping using distinct
itonavir-boosted protease inhibitors.
Barreiro P, Camino N, de Mendoza C, et al. 
Int J Antimicrob Agents 2002 Dec;20(6):438-443
 Abstract

Persistence of HIV-1 resistance in lymph node mononuclear cell RNA despite effective HAART.
Lafeuillade A, Khiri H, Chadapaud S, et al.
AIDS 2001 Oct 19;15(15):1965-9
Abstract

A highly prevalent polymorphism at codon 72 of HIV-1 reverse transcriptase |in Argentina
prevents hybridization reaction at codon74 in the LiPA genotyping test.
Kijak GH, Carobene MG, Salomon H.  et al
Virol Methods 2001 May;94(1-2):87-95
Abstract

Prevalence of genotypic resistance among antiretroviral drug-naive HIV-1-
infected patients in Belgium.  
Van Vaerenbergh K, Debaisieux L, De Cabooter N, et al. 
Antivir Ther 2001 Mar;6(1):63-70
Abstract

  
Brand Index
       

Visible Genetics (TRUGENE HIV-1 Genotyping Kit and OpenGene System)

     Journal Papers, Abstracts, and Commentaries  

 
Study of resistance using the TRUGENE HIV-1 genotyping system and analysis of
agreement between rule-based algorithms and virtual phenotyping.
Nogales MC, Serrano MC, Bernal S, Jarana R, et al 
Enferm Infecc Microbiol Clin. 2005 Mar;23(3):149-55
 Abstract
 
Conflicting interpretations of the prevalence of mutations associated with drug resistance in
antiviral naive HIV-1 patients with acute and chronic infection.
 Re MC, Monari P, Bon I,  
Int J Antimicrob Agents. 2004 Feb;23(2):164-8.
 Abstract

Stability of Human Immunodeficiency Virus Type 1 RNA in Cerebrospinal Fluid Determined
with the AMPLICOR HIV-1MONITOR Test, Version 1.5 (Ultrasensitive).
Singer EJ, Aronow HA, Lee SY,  et al
J Clin Microbiol 2002 Oct;40(10):3863-3864
 Abstract

  

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Genotype Testing for HIV Drug Resistance